Assay Detail
Binding
CHEMBL919694
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Inhibition of GST-tagged bovine PI3K p110-alpha by SPA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL2498) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.39 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223071 | — | — | 1 | 8.74 |
| CHEMBL541133 | — | — | 1 | 8.55 |
| CHEMBL224513 | — | — | 1 | 8.55 |
| CHEMBL224769 | — | — | 1 | 8.51 |
| CHEMBL536293 | — | — | 1 | 7.70 |
| CHEMBL553488 | — | — | 1 | 7.51 |
| CHEMBL558973 | — | — | 1 | 7.09 |
| CHEMBL536292 | — | — | 1 | 7.00 |
| CHEMBL223070 | — | — | 1 | 6.55 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.20 |
| CHEMBL427066 | — | — | 1 | 6.17 |
| CHEMBL376533 | — | — | 1 | 6.12 |
| CHEMBL224656 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223071 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL541133 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL224513 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL224769 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL536293 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL553488 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL558973 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL536292 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL223070 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL98350 | LY-294002 | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL427066 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL376533 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL224656 | — | IC50 | > | 30000.0 | nM | - |