Assay Detail
Functional
CHEMBL919715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human A431 cells by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.03 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL225561 | — | — | 1 | 6.12 |
| CHEMBL224765 | — | — | 1 | 5.88 |
| CHEMBL387906 | — | — | 1 | 5.84 |
| CHEMBL225616 | — | — | 1 | 5.61 |
| CHEMBL448783 | — | — | 1 | 5.41 |
| CHEMBL224234 | — | — | 1 | - |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | - |
| CHEMBL225452 | — | — | 1 | - |
| CHEMBL390084 | — | — | 1 | - |
| CHEMBL225400 | — | — | 1 | - |
| CHEMBL225399 | — | — | 1 | - |
| CHEMBL388578 | — | — | 1 | - |
| CHEMBL225060 | — | — | 1 | - |
| CHEMBL225005 | — | — | 1 | - |
| CHEMBL224630 | — | — | 1 | - |
| CHEMBL224587 | — | — | 1 | - |
| CHEMBL225255 | — | — | 1 | - |
| CHEMBL224511 | — | — | 1 | - |
| CHEMBL224351 | — | — | 1 | - |
| CHEMBL224298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL225561 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL224765 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL387906 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL225616 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL448783 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL224234 | — | IC50 | - | — | - | |
| CHEMBL803 | CYTARABINE | IC50 | - | — | - | |
| CHEMBL225452 | — | IC50 | - | — | - | |
| CHEMBL390084 | — | IC50 | - | — | - | |
| CHEMBL225400 | — | IC50 | - | — | - | |
| CHEMBL225399 | — | IC50 | - | — | - | |
| CHEMBL388578 | — | IC50 | - | — | - | |
| CHEMBL225060 | — | IC50 | - | — | - | |
| CHEMBL225005 | — | IC50 | - | — | - | |
| CHEMBL224630 | — | IC50 | - | — | - | |
| CHEMBL224587 | — | IC50 | - | — | - | |
| CHEMBL225255 | — | IC50 | - | — | - | |
| CHEMBL224511 | — | IC50 | - | — | - | |
| CHEMBL224351 | — | IC50 | - | — | - | |
| CHEMBL224298 | — | IC50 | - | — | - |