Assay Detail
Functional
CHEMBL920032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction of HIV1-p24 antigen production in HIV1-3 Ba-L infected macrophages
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.02 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223769 | — | — | 1 | 8.70 |
| CHEMBL225004 | — | — | 1 | 8.08 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223769 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL225004 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 53.0 | nM | 7.28 |