Assay Detail
Binding
CHEMBL920440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 by HTRF assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.44 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374330 | — | — | 1 | 8.70 |
| CHEMBL376077 | — | — | 1 | 8.52 |
| CHEMBL375670 | — | — | 1 | 8.52 |
| CHEMBL376307 | — | — | 1 | 8.30 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 8.30 |
| CHEMBL374044 | — | — | 1 | 8.15 |
| CHEMBL387312 | — | — | 1 | 8.10 |
| CHEMBL424943 | — | — | 1 | 8.00 |
| CHEMBL220057 | — | — | 1 | 7.92 |
| CHEMBL222315 | — | — | 1 | 7.89 |
| CHEMBL219727 | — | — | 1 | 7.89 |
| CHEMBL374752 | — | — | 1 | 7.85 |
| CHEMBL376245 | — | — | 1 | 7.82 |
| CHEMBL223478 | — | — | 1 | 7.62 |
| CHEMBL373798 | — | — | 1 | 7.60 |
| CHEMBL220049 | — | — | 1 | 7.58 |
| CHEMBL223304 | — | — | 1 | 7.58 |
| CHEMBL219998 | — | — | 1 | 7.54 |
| CHEMBL223528 | — | — | 1 | 7.47 |
| CHEMBL426887 | — | — | 1 | 7.41 |
| CHEMBL222778 | — | — | 1 | 7.37 |
| CHEMBL426004 | — | — | 1 | 7.33 |
| CHEMBL219722 | — | — | 1 | 7.27 |
| CHEMBL221053 | — | — | 1 | 7.26 |
| CHEMBL219774 | — | — | 1 | 7.22 |
| CHEMBL438653 | — | — | 1 | 7.14 |
| CHEMBL222728 | — | — | 1 | 6.97 |
| CHEMBL223790 | — | — | 1 | 6.92 |
| CHEMBL223583 | — | — | 1 | 6.80 |
| CHEMBL373845 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374330 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL376077 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL375670 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL376307 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL223360 | LINIFANIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL374044 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL387312 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL424943 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL220057 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL219727 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL222315 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL374752 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL376245 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL223478 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL373798 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL220049 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL223304 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL219998 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL223528 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL426887 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL222778 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL426004 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL219722 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL221053 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL219774 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL438653 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL222728 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL223790 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL223583 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL373845 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL223361 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL219999 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL223572 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL223236 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL223185 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL223237 | — | IC50 | = | 860.0 | nM | 6.07 |