Compound Detail
CHEMBL426887
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Basic Information
| ChEMBL ID | CHEMBL426887 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUAVZPFKUWDJJL-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
335.4
MW (Da)
3.88
ALogP
3
HBA
4
HBD
95.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.41 | 7.41 | 39.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.82 | 6.82 | 153.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.07 | 6.07 | 850.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 39.0 | nM | 7.41 | Inhibition of FLT3 by HTRF assay | 17343372 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 153.0 | nM | 6.82 | Inhibition of KDR by HTRF assay | 17343372 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 850.0 | nM | 6.07 | Inhibition of c-Kit by HTRF assay | 17343372 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 850.0 | nM | 6.07 | Inhibition of c-Kit by HTRF method | 19892442 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17343372 | 10.1021/jm061280h | Vascular endothelial growth factor receptor 2 | 1 |
| 17343372 | 10.1021/jm061280h | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 17343372 | 10.1021/jm061280h | Mast/stem cell growth factor receptor Kit | 1 |
| 19892442 | 10.1016/j.ejmech.2009.09.013 | Mast/stem cell growth factor receptor Kit | 1 |
Data from ChEMBL 36 via Core Engine