Assay Detail
Binding
CHEMBL920441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Kit by HTRF assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.23 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374752 | — | — | 1 | 8.30 |
| CHEMBL219887 | — | — | 1 | 8.00 |
| CHEMBL374044 | — | — | 1 | 8.00 |
| CHEMBL375670 | — | — | 1 | 7.89 |
| CHEMBL373798 | — | — | 1 | 7.82 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 7.80 |
| CHEMBL374330 | — | — | 1 | 7.77 |
| CHEMBL220057 | — | — | 1 | 7.77 |
| CHEMBL220049 | — | — | 1 | 7.70 |
| CHEMBL223790 | — | — | 1 | 7.58 |
| CHEMBL219998 | — | — | 1 | 7.55 |
| CHEMBL223528 | — | — | 1 | 7.50 |
| CHEMBL223583 | — | — | 1 | 7.47 |
| CHEMBL219727 | — | — | 1 | 7.41 |
| CHEMBL424943 | — | — | 1 | 7.39 |
| CHEMBL426004 | — | — | 1 | 7.38 |
| CHEMBL376307 | — | — | 1 | 7.38 |
| CHEMBL221053 | — | — | 1 | 7.38 |
| CHEMBL219722 | — | — | 1 | 7.36 |
| CHEMBL223304 | — | — | 1 | 7.32 |
| CHEMBL223478 | — | — | 1 | 7.30 |
| CHEMBL376245 | — | — | 1 | 7.28 |
| CHEMBL219774 | — | — | 1 | 7.21 |
| CHEMBL438653 | — | — | 1 | 7.19 |
| CHEMBL222728 | — | — | 1 | 7.16 |
| CHEMBL376077 | — | — | 1 | 7.07 |
| CHEMBL222315 | — | — | 1 | 6.82 |
| CHEMBL223361 | — | — | 1 | 6.82 |
| CHEMBL373845 | — | — | 1 | 6.54 |
| CHEMBL223572 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374752 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL219887 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL374044 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL375670 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL373798 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL223360 | LINIFANIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL374330 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL220057 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL220049 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL223790 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL219998 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL223528 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL223583 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL219727 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL424943 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL376307 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL426004 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL221053 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL219722 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL223304 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL223478 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL376245 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL219774 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL438653 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL222728 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL376077 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL222315 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL223361 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL373845 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL223572 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL426887 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL222778 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL220317 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL223185 | — | IC50 | > | 12500.0 | nM | - |