Compound Detail
CHEMBL220317
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Basic Information
| ChEMBL ID | CHEMBL220317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEZDURDPMARJKQ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
364.4
MW (Da)
3.61
ALogP
4
HBA
3
HBD
100.9
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.33 | 5.33 | 4620.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 4.95 | 4.95 | 11200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4620.0 | nM | 5.33 | Inhibition of KDR by HTRF assay | 17343372 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 11200.0 | nM | 4.95 | Inhibition of c-Kit by HTRF assay | 17343372 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 11200.0 | nM | 4.95 | Inhibition of c-Kit by HTRF method | 19892442 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17343372 | 10.1021/jm061280h | Vascular endothelial growth factor receptor 2 | 1 |
| 17343372 | 10.1021/jm061280h | Mast/stem cell growth factor receptor Kit | 1 |
| 19892442 | 10.1016/j.ejmech.2009.09.013 | Mast/stem cell growth factor receptor Kit | 1 |
Data from ChEMBL 36 via Core Engine