Assay Detail
Binding
CHEMBL920439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR by HTRF assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.23 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219887 | — | — | 1 | 8.52 |
| CHEMBL220057 | — | — | 1 | 8.52 |
| CHEMBL374044 | — | — | 1 | 8.40 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 8.40 |
| CHEMBL374752 | — | — | 1 | 8.30 |
| CHEMBL221053 | — | — | 1 | 8.22 |
| CHEMBL375670 | — | — | 1 | 8.10 |
| CHEMBL219727 | — | — | 1 | 8.00 |
| CHEMBL424943 | — | — | 1 | 8.00 |
| CHEMBL387312 | — | — | 1 | 7.96 |
| CHEMBL374330 | — | — | 1 | 7.92 |
| CHEMBL223129 | — | — | 1 | 7.89 |
| CHEMBL376307 | — | — | 1 | 7.82 |
| CHEMBL375284 | — | — | 1 | 7.75 |
| CHEMBL223528 | — | — | 1 | 7.68 |
| CHEMBL222817 | — | — | 1 | 7.68 |
| CHEMBL223478 | — | — | 1 | 7.68 |
| CHEMBL373798 | — | — | 1 | 7.64 |
| CHEMBL376245 | — | — | 1 | 7.60 |
| CHEMBL219998 | — | — | 1 | 7.58 |
| CHEMBL223790 | — | — | 1 | 7.51 |
| CHEMBL219774 | — | — | 1 | 7.46 |
| CHEMBL222728 | — | — | 1 | 7.44 |
| CHEMBL426004 | — | — | 1 | 7.44 |
| CHEMBL438653 | — | — | 1 | 7.42 |
| CHEMBL223304 | — | — | 1 | 7.26 |
| CHEMBL219722 | — | — | 1 | 7.19 |
| CHEMBL220049 | — | — | 1 | 7.17 |
| CHEMBL221574 | — | — | 1 | 7.13 |
| CHEMBL223583 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219887 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL220057 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223360 | LINIFANIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL374044 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL374752 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL221053 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL375670 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL219727 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL424943 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL387312 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL374330 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL223129 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL376307 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL375284 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL223478 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL223528 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL222817 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL373798 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL376245 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL219998 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL223790 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL219774 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL222728 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL426004 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL438653 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL223304 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL219722 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL220049 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL221574 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL223583 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL222315 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL376077 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL223361 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL426887 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL223572 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL222974 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL219999 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL373845 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL223237 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL223236 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL222918 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL220317 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL222778 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL373435 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL223185 | — | IC50 | > | 12500.0 | nM | - |