Assay Detail
Binding
CHEMBL920536
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Inhibition of tubulin polymerization
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Identification of novel and improved antimitotic agents derived from noscapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.46 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.70 |
| CHEMBL376130 | — | — | 1 | 6.52 |
| CHEMBL224797 | — | — | 1 | 6.16 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL376130 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL224797 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL364713 | NOSCAPINE | EC50 | > | 50000.0 | nM | - |