Assay Detail
Binding
CHEMBL920799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP 39653 from NMDA receptor in rat synaptosomes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.06 | 4.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388746 | — | — | 1 | 4.06 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | - |
| CHEMBL227922 | — | — | 1 | - |
| CHEMBL193087 | — | — | 1 | - |
| CHEMBL372643 | — | — | 1 | - |
| CHEMBL370941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388746 | — | Ki | = | 87000.0 | nM | 4.06 |
| CHEMBL13378 | (R,S)-AMPA | Ki | > | 100000.0 | nM | - |
| CHEMBL227922 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL193087 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL372643 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL370941 | — | Ki | > | 100000.0 | nM | - |