Assay Detail
Functional
CHEMBL921333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity in human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by XTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.54 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408517 | — | — | 1 | 6.47 |
| CHEMBL259357 | — | — | 1 | 5.94 |
| CHEMBL265944 | — | — | 1 | 5.71 |
| CHEMBL406118 | — | — | 1 | 5.50 |
| CHEMBL408502 | — | — | 1 | 5.43 |
| CHEMBL410082 | — | — | 1 | 5.33 |
| CHEMBL261135 | — | — | 1 | 4.99 |
| CHEMBL259509 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408517 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL259357 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL265944 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL406118 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL408502 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL410082 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL261135 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL259509 | — | IC50 | = | 10800.0 | nM | 4.97 |