Assay Detail
Binding
CHEMBL921473
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Binding affinity at human adenosine A2A receptor
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 67 | 7.73 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261203 | — | — | 1 | 9.00 |
| CHEMBL409915 | — | — | 1 | 9.00 |
| CHEMBL429144 | — | — | 1 | 9.00 |
| CHEMBL259049 | — | — | 1 | 9.00 |
| CHEMBL411034 | — | — | 1 | 9.00 |
| CHEMBL260146 | — | — | 1 | 9.00 |
| CHEMBL257757 | — | — | 1 | 9.00 |
| CHEMBL264432 | — | — | 1 | 9.00 |
| CHEMBL259832 | — | — | 1 | 8.70 |
| CHEMBL409682 | — | — | 1 | 8.70 |
| CHEMBL401973 | — | — | 1 | 8.70 |
| CHEMBL402409 | — | — | 1 | 8.70 |
| CHEMBL402172 | — | — | 1 | 8.52 |
| CHEMBL259418 | — | — | 1 | 8.52 |
| CHEMBL371615 | — | — | 1 | 8.52 |
| CHEMBL403252 | — | — | 1 | 8.40 |
| CHEMBL256361 | — | — | 1 | 8.40 |
| CHEMBL256360 | — | — | 1 | 8.40 |
| CHEMBL258181 | — | — | 1 | 8.40 |
| CHEMBL407049 | — | — | 1 | 8.40 |
| CHEMBL260209 | — | — | 1 | 8.30 |
| CHEMBL260989 | — | — | 1 | 8.22 |
| CHEMBL424827 | — | — | 1 | 8.22 |
| CHEMBL261534 | — | — | 1 | 8.22 |
| CHEMBL256344 | — | — | 1 | 8.22 |
| CHEMBL371436 | — | — | 1 | 8.15 |
| CHEMBL410033 | — | — | 1 | 8.10 |
| CHEMBL261349 | — | — | 1 | 8.10 |
| CHEMBL403470 | — | — | 1 | 8.10 |
| CHEMBL257756 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261203 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL264432 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL257757 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL260146 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL411034 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL429144 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL409915 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL259049 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL402409 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL259832 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL401973 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL409682 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL402172 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL259418 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL371615 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL403252 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL256361 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL256360 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL258181 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL407049 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL260209 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL260989 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL424827 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL261534 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL256344 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL371436 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL261349 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL403470 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL410033 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL257756 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL258006 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL257982 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL264431 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL411473 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL406298 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL267200 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL410678 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL259164 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL402389 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL260788 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL409152 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL410679 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL256359 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL259416 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL437804 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL196436 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL260721 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL405789 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL260557 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL258960 | — | Ki | = | 56.0 | nM | 7.25 |