Assay Detail
Functional
CHEMBL921485
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Antiviral activity against HIV1 3B assessed as inhibition of viral-induced cytopathic effect in human MT4 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.93 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 9.10 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.89 |
| CHEMBL259011 | — | — | 1 | 6.23 |
| CHEMBL260185 | — | — | 1 | 5.67 |
| CHEMBL263887 | — | — | 1 | 5.50 |
| CHEMBL260398 | — | — | 1 | 5.39 |
| CHEMBL409643 | — | — | 1 | 5.25 |
| CHEMBL261714 | — | — | 1 | 5.15 |
| CHEMBL261541 | — | — | 1 | 5.08 |
| CHEMBL259012 | — | — | 1 | 5.08 |
| CHEMBL406929 | — | — | 1 | 4.94 |
| CHEMBL405652 | — | — | 1 | - |
| CHEMBL260619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL259011 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL260185 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL263887 | — | EC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL260398 | — | EC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL409643 | — | EC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL261714 | — | EC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL261541 | — | EC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL259012 | — | EC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL406929 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL405652 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL260619 | — | EC50 | > | 100000.0 | nM | - |