Assay Detail
Binding
CHEMBL921624
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Inhibition of IRAK1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 1 (CHEMBL3357) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.33 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401633 | — | — | 1 | 4.64 |
| CHEMBL255873 | — | — | 1 | 4.02 |
| CHEMBL402629 | — | — | 1 | - |
| CHEMBL256961 | — | — | 1 | - |
| CHEMBL256963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401633 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL255873 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL402629 | — | IC50 | = | 293000.0 | nM | - |
| CHEMBL256961 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL256963 | — | IC50 | = | 195000.0 | nM | - |