Compound Detail
CHEMBL256963
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Basic Information
| ChEMBL ID | CHEMBL256963 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RDTAHMIMQLRAMR-UHFFFAOYSA-N |
4
Targets
7
Activities
1
Assay Types
4
PK Parameters
8
Publications
0
Known Names
Molecular Properties
299.8
MW (Da)
2.43
ALogP
5
HBA
2
HBD
54.2
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 CHEMBL3778 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.35 | 6.64 | 45.0 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.93 | 5.93 | 1177.0 | 1 |
| GTPase NRas CHEMBL2079845 | IC50 | 4.78 | 4.78 | 16630.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 13.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.01 | mL.min-1.g-1 | Rattus norvegicus |
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 19.05 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of IRAK4 | 18501603 |
| Unchecked | IC50 | = | 45.0 | nM | 7.35 | HotSpot Assay: Table 3 and 4: The HotSpot kinase profiling and screening assays ... | - |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 1177.0 | nM | 5.93 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| Unchecked | IC50 | = | 1177.0 | nM | 5.93 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
| GTPase NRas | IC50 | = | 16630.0 | nM | 4.78 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| GTPase NRas | IC50 | = | 16630.0 | nM | 4.78 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3301361 | ADMET | 3 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | ADMET | 2 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | Interleukin-1 receptor-associated kinase 4 | 1 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | Interleukin-1 receptor-associated kinase 1 | 1 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | PBMC | 1 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | Cytochrome P450 3A4 | 1 |
| 18501603 | 10.1016/j.bmcl.2008.04.042 | Cytochrome P450 2D6 | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine