Assay Detail
Binding
CHEMBL921622
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Inhibition of IRAK4
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.12 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256570 | — | — | 1 | 9.00 |
| CHEMBL401633 | — | — | 1 | 9.00 |
| CHEMBL255867 | — | — | 1 | 8.70 |
| CHEMBL436653 | — | — | 1 | 8.52 |
| CHEMBL255873 | — | — | 1 | 8.40 |
| CHEMBL403358 | — | — | 1 | 8.30 |
| CHEMBL256963 | — | — | 1 | 8.22 |
| CHEMBL402629 | — | — | 1 | 8.22 |
| CHEMBL403433 | — | — | 1 | 8.15 |
| CHEMBL255446 | — | — | 1 | 8.15 |
| CHEMBL402361 | — | — | 1 | 8.10 |
| CHEMBL256961 | — | — | 1 | 8.05 |
| CHEMBL404473 | — | — | 1 | 8.00 |
| CHEMBL402174 | — | — | 1 | 7.82 |
| CHEMBL256504 | — | — | 1 | 7.72 |
| CHEMBL258004 | — | — | 1 | 7.46 |
| CHEMBL437208 | — | — | 1 | 7.41 |
| CHEMBL256733 | — | — | 1 | 7.31 |
| CHEMBL255445 | — | — | 1 | 7.20 |
| CHEMBL255272 | — | — | 1 | 7.16 |
| CHEMBL403210 | — | — | 1 | 7.02 |
| CHEMBL403442 | — | — | 1 | 6.95 |
| CHEMBL402080 | — | — | 1 | 6.90 |
| CHEMBL256942 | — | — | 1 | 6.78 |
| CHEMBL402612 | — | — | 1 | 6.74 |
| CHEMBL255935 | — | — | 1 | 6.68 |
| CHEMBL255098 | — | — | 1 | 6.67 |
| CHEMBL402295 | — | — | 1 | 6.65 |
| CHEMBL256735 | — | — | 1 | 6.58 |
| CHEMBL403395 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256570 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL401633 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL255867 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL436653 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL255873 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL403358 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL256963 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL402629 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL403433 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL255446 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL402361 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL256961 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL404473 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL402174 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL256504 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL258004 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL437208 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL256733 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL255445 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL255272 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL403210 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL403442 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL402080 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL256942 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL402612 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL255935 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL255098 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL402295 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL256735 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL403395 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL404471 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL403490 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL258024 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL404142 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL402344 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL255253 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL404472 | — | IC50 | = | 1085.0 | nM | 5.96 |
| CHEMBL258233 | — | IC50 | = | 1134.0 | nM | 5.95 |
| CHEMBL256734 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL256513 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL402079 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL255439 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL258025 | — | IC50 | = | 8100.0 | nM | 5.09 |