Assay Detail
Binding
CHEMBL5737865
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AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.
69
Total Activities
23
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.26 | 8.70 |
| kon | 23 | - | - |
| k_off | 23 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6038112 | — | — | 3 | 8.70 |
| CHEMBL5953482 | — | — | 3 | 6.20 |
| CHEMBL401633 | — | — | 3 | 5.75 |
| CHEMBL6012486 | — | — | 3 | 5.74 |
| CHEMBL5968312 | — | — | 3 | 5.73 |
| CHEMBL5920310 | — | — | 3 | 5.43 |
| CHEMBL5971424 | — | — | 3 | 5.37 |
| CHEMBL5842222 | — | — | 3 | 5.35 |
| CHEMBL5917089 | — | — | 3 | 5.35 |
| CHEMBL6055101 | — | — | 3 | 5.25 |
| CHEMBL5945243 | — | — | 3 | 5.03 |
| CHEMBL6002371 | — | — | 3 | 5.00 |
| CHEMBL5942885 | — | — | 3 | 4.83 |
| CHEMBL5884915 | — | — | 3 | 4.80 |
| CHEMBL5918176 | — | — | 3 | 4.80 |
| CHEMBL6006619 | — | — | 3 | 4.78 |
| CHEMBL6025418 | — | — | 3 | 4.78 |
| CHEMBL256963 | — | — | 3 | 4.78 |
| CHEMBL5768661 | — | — | 3 | 4.78 |
| CHEMBL5900939 | — | — | 3 | 4.75 |
| CHEMBL3182364 | — | — | 3 | 4.68 |
| CHEMBL5760981 | — | — | 3 | 4.53 |
| CHEMBL5949720 | — | — | 3 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6038112 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5953482 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL401633 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL6012486 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5968312 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5920310 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5971424 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL5917089 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL5842222 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL6055101 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL5945243 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL6002371 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL5942885 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL5884915 | — | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL5918176 | — | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL5768661 | — | IC50 | = | 16630.0 | nM | 4.78 |
| CHEMBL6006619 | — | IC50 | = | 16630.0 | nM | 4.78 |
| CHEMBL256963 | — | IC50 | = | 16630.0 | nM | 4.78 |
| CHEMBL6025418 | — | IC50 | = | 16630.0 | nM | 4.78 |
| CHEMBL5900939 | — | IC50 | = | 17640.0 | nM | 4.75 |
| CHEMBL3182364 | — | IC50 | = | 20930.0 | nM | 4.68 |
| CHEMBL5760981 | — | IC50 | = | 29760.0 | nM | 4.53 |
| CHEMBL5949720 | — | IC50 | = | 33170.0 | nM | 4.48 |
| CHEMBL6002371 | — | k_off | = | - | s-1 | - |
| CHEMBL5768661 | — | k_off | = | - | s-1 | - |
| CHEMBL256963 | — | k_off | = | - | s-1 | - |
| CHEMBL5842222 | — | kon | = | - | — | - |
| CHEMBL3182364 | — | kon | = | - | — | - |
| CHEMBL3182364 | — | k_off | = | - | s-1 | - |
| CHEMBL5942885 | — | k_off | = | - | s-1 | - |
| CHEMBL5949720 | — | kon | = | - | — | - |
| CHEMBL5949720 | — | k_off | = | - | s-1 | - |
| CHEMBL6002371 | — | kon | = | - | — | - |
| CHEMBL6012486 | — | kon | = | - | — | - |
| CHEMBL6012486 | — | k_off | = | - | s-1 | - |
| CHEMBL5918176 | — | kon | = | - | — | - |
| CHEMBL256963 | — | kon | = | - | — | - |
| CHEMBL5768661 | — | kon | = | - | — | - |
| CHEMBL401633 | — | kon | = | - | — | - |
| CHEMBL5900939 | — | k_off | = | - | s-1 | - |
| CHEMBL5900939 | — | kon | = | - | — | - |
| CHEMBL5953482 | — | k_off | = | - | s-1 | - |
| CHEMBL401633 | — | k_off | = | - | s-1 | - |
| CHEMBL5953482 | — | kon | = | - | — | - |
| CHEMBL5971424 | — | k_off | = | - | s-1 | - |
| CHEMBL6055101 | — | k_off | = | - | s-1 | - |
| CHEMBL5968312 | — | kon | = | - | — | - |
| CHEMBL6055101 | — | kon | = | - | — | - |
| CHEMBL5971424 | — | kon | = | - | — | - |
| CHEMBL5968312 | — | k_off | = | - | s-1 | - |