Compound Detail
CHEMBL5884915
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Basic Information
| ChEMBL ID | CHEMBL5884915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BSPADJDNBJNBEV-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
488.6
MW (Da)
2.37
ALogP
10
HBA
2
HBD
93.8
PSA (Ų)
0.39
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| GTPase NRas CHEMBL2079845 | IC50 | 4.8 | 4.8 | 15720.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 20.0 | nM | 7.7 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| Unchecked | IC50 | = | 20.0 | nM | 7.7 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
| GTPase NRas | IC50 | = | 15720.0 | nM | 4.8 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| GTPase NRas | IC50 | = | 15720.0 | nM | 4.8 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
Data from ChEMBL 36 via Core Engine