Compound Detail
CHEMBL6025418
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Basic Information
| ChEMBL ID | CHEMBL6025418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AQWWUSFIMPALTH-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
2.57
ALogP
7
HBA
3
HBD
92.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.65 | 5.65 | 2221.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.65 | 5.65 | 2221.0 | 1 |
| GTPase NRas CHEMBL2079845 | IC50 | 4.78 | 4.78 | 16630.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 2221.0 | nM | 5.65 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| Unchecked | IC50 | = | 2221.0 | nM | 5.65 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
| GTPase NRas | IC50 | = | 16630.0 | nM | 4.78 | AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin E... | - |
| GTPase NRas | IC50 | = | 16630.0 | nM | 4.78 | IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with ... | - |
Data from ChEMBL 36 via Core Engine