Assay Detail

CHEMBL921731

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Binding

Inhibition of mouse COX2 pre-incubated before addition of [1-14C]arachidonic acid

ChEMBL ↗

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Target

Prostaglandin G/H synthase 2 (CHEMBL4321) ↗

Open DB target context

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Prostaglandin G/H synthase 2 (CHEMBL4321) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin G/H synthase 2

CHEMBL4321

Anchored from Assay target.

Protein identity Prostaglandin G/H synthase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL4321) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.

Blobaum AL, Marnett LJ.
J Biol Chem (2007) 282 : 16379 -16390
PubMed 17434872 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.09	6.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL259218	—	—	1	6.09
CHEMBL404108	LUMIRACOXIB	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL259218	—	Ki	=	820.0	nM	6.09
CHEMBL404108	LUMIRACOXIB	Ki		-	—	-