Assay Detail
Binding
CHEMBL921793
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Inhibition of mouse COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acid
8
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.22 | 7.66 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.66 |
| CHEMBL76084 | — | — | 1 | 7.46 |
| CHEMBL259218 | — | — | 2 | 7.20 |
| CHEMBL407368 | — | — | 2 | 7.03 |
| CHEMBL259842 | — | — | 1 | 6.76 |
| CHEMBL404108 | LUMIRACOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL76084 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL259218 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL407368 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL259842 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL404108 | LUMIRACOXIB | Inhibition | = | 15.0 | % | - |
| CHEMBL259218 | — | Inhibition | = | 85.0 | % | - |
| CHEMBL407368 | — | Inhibition | = | 85.0 | % | - |