Assay Detail
Functional
CHEMBL921912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human VDR in COS7 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.99 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 9.30 |
| CHEMBL429347 | — | — | 1 | 8.22 |
| CHEMBL409470 | — | — | 1 | 8.00 |
| CHEMBL263638 | — | — | 1 | 7.60 |
| CHEMBL261197 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL429347 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL409470 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL263638 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL261197 | — | EC50 | = | 150.0 | nM | 6.82 |