Assay Detail
Functional
CHEMBL921967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.10 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76781 | — | — | 1 | 8.62 |
| CHEMBL407909 | — | — | 1 | 8.49 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.24 |
| CHEMBL272942 | MECOPROP | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76781 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL407909 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL39 | SEROTONIN | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL272942 | MECOPROP | EC50 | = | 93.0 | nM | 7.03 |