Assay Detail
Functional
CHEMBL922121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | DDT1MF-2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.41 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411245 | — | — | 1 | 9.92 |
| CHEMBL258759 | — | — | 1 | 9.52 |
| CHEMBL410288 | — | — | 1 | 9.05 |
| CHEMBL427737 | — | — | 1 | 8.59 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.57 |
| CHEMBL262604 | — | — | 1 | 8.15 |
| CHEMBL412104 | — | — | 1 | 7.92 |
| CHEMBL258972 | — | — | 1 | 7.82 |
| CHEMBL263643 | — | — | 1 | 7.68 |
| CHEMBL258760 | — | — | 1 | 7.68 |
| CHEMBL260631 | — | — | 1 | 7.55 |
| CHEMBL262876 | — | — | 1 | 7.32 |
| CHEMBL258489 | — | — | 1 | 7.17 |
| CHEMBL260205 | — | — | 1 | 6.65 |
| CHEMBL265947 | — | — | 1 | 6.46 |
| CHEMBL279161 | — | — | 1 | 6.39 |
| CHEMBL262850 | — | — | 1 | 6.22 |
| CHEMBL411859 | — | — | 1 | 6.15 |
| CHEMBL442468 | — | — | 1 | 6.06 |
| CHEMBL411463 | — | — | 1 | 5.37 |
| CHEMBL411279 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411245 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL258759 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL410288 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL427737 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL262604 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL412104 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL258972 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL263643 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL258760 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL260631 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL262876 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL258489 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL260205 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL265947 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL279161 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL262850 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL411859 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL442468 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL411463 | — | IC50 | = | 4279.0 | nM | 5.37 |
| CHEMBL411279 | — | IC50 | = | 4950.0 | nM | 5.30 |