Assay Detail
Functional
CHEMBL922189
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Antiviral activity against Simian virus 40 PML2 DAR in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Betapolyomavirus macacae |
| Cell Type | BSC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.93 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240167 | — | — | 1 | 6.47 |
| CHEMBL261691 | — | — | 1 | 5.14 |
| CHEMBL286534 | — | — | 1 | 4.99 |
| CHEMBL219724 | — | — | 1 | 4.79 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.75 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | 4.73 |
| CHEMBL238664 | — | — | 1 | 4.72 |
| CHEMBL112159 | — | — | 1 | 4.42 |
| CHEMBL261240 | — | — | 1 | 4.33 |
| CHEMBL298845 | — | — | 1 | - |
| CHEMBL265719 | — | — | 1 | - |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240167 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL261691 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL286534 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL219724 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL238664 | — | EC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL112159 | — | EC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL261240 | — | EC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL298845 | — | EC50 | = | 181200.0 | nM | - |
| CHEMBL265719 | — | EC50 | = | 112500.0 | nM | - |
| CHEMBL484 | ADEFOVIR | EC50 | = | 125900.0 | nM | - |