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Assay Detail

CHEMBL922513

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CGP-39653 from NMDA receptor in rat cortical membrane
14
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Glutamate NMDA receptor (CHEMBL1907608)
Type PROTEIN COMPLEX GROUP
Organism Rattus norvegicus

Publication

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
Pinto A, Conti P, De Amici M, Tamborini L, Madsen U, Nielsen B, Christesen T, Bräuner-Osborne H, De Micheli C.
J Med Chem (2008) 51 : 2311 -2315
PubMed 18338843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 4.80 6.19
IC50 4 4.98 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL260327 2 6.19
CHEMBL408899 TRICHOLOMIC ACID 4 5.82
CHEMBL30285 IBOTENIC ACID 2 5.28
CHEMBL260328 2 4.40
CHEMBL406621 2 4.13
CHEMBL260122 2 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL260327 Ki = 645.65 nM 6.19
CHEMBL260327 Ki = 670.0 nM 6.17
CHEMBL408899 TRICHOLOMIC ACID IC50 = 1500.0 nM 5.82
CHEMBL408899 TRICHOLOMIC ACID IC50 = 1513.56 nM 5.82
CHEMBL30285 IBOTENIC ACID Ki = 5300.0 nM 5.28
CHEMBL30285 IBOTENIC ACID Ki = 5248.07 nM 5.28
CHEMBL260328 Ki = 39810.72 nM 4.40
CHEMBL260328 Ki = 41000.0 nM 4.39
CHEMBL408899 TRICHOLOMIC ACID IC50 = 73000.0 nM 4.14
CHEMBL408899 TRICHOLOMIC ACID IC50 = 72443.6 nM 4.14
CHEMBL406621 Ki = 74131.02 nM 4.13
CHEMBL406621 Ki = 75000.0 nM 4.12
CHEMBL260122 Ki = 93325.43 nM 4.03
CHEMBL260122 Ki = 95000.0 nM 4.02