Assay Detail
Functional
CHEMBL922692
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Cytotoxicity against mouse MHEC5-T cells after 5 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MHEC5-T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.47 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 8.70 |
| CHEMBL256278 | — | — | 1 | 8.37 |
| CHEMBL94021 | — | — | 1 | 8.34 |
| CHEMBL402068 | — | — | 1 | - |
| CHEMBL256283 | — | — | 1 | - |
| CHEMBL404231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL256278 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL94021 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL402068 | — | IC50 | > | 1400.0 | nM | - |
| CHEMBL256283 | — | IC50 | > | 1400.0 | nM | - |
| CHEMBL404231 | — | IC50 | > | 1400.0 | nM | - |