Assay Detail
Binding
CHEMBL923036
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Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cells
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.93 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.58 |
| CHEMBL1162116 | — | — | 1 | 8.44 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 7.93 |
| CHEMBL77793 | — | — | 1 | 6.99 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 6.97 |
| CHEMBL134641 | SABCOMELINE | 2.0 | 1 | 6.69 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.49 |
| CHEMBL12587 | MUSCARINE | — | 1 | 6.31 |
| CHEMBL608828 | (S)-ACECLIDINE | — | 1 | 6.21 |
| CHEMBL259344 | — | — | 1 | 6.17 |
| CHEMBL151938 | MILAMELINE | 2.0 | 1 | 6.00 |
| CHEMBL105457 | — | — | 1 | 5.92 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.88 |
| CHEMBL258907 | — | — | 1 | 5.85 |
| CHEMBL402473 | — | — | 1 | 5.77 |
| CHEMBL320820 | — | — | 1 | 5.68 |
| CHEMBL612034 | (R)-ACECLIDINE | — | 1 | 5.65 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.61 |
| CHEMBL294273 | — | — | 1 | 5.56 |
| CHEMBL258906 | — | — | 1 | 5.45 |
| CHEMBL259131 | — | — | 1 | 5.30 |
| CHEMBL258905 | — | — | 1 | 5.28 |
| CHEMBL541424 | — | — | 3 | 5.03 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 4.92 |
| CHEMBL259662 | — | — | 1 | 4.43 |
| CHEMBL553241 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL1162116 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL21536 | XANOMELINE | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL77793 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL134641 | SABCOMELINE | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL12587 | MUSCARINE | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL608828 | (S)-ACECLIDINE | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL259344 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL151938 | MILAMELINE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL105457 | — | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL14 | CARBACHOL | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL258907 | — | Ki | = | 1412.54 | nM | 5.85 |
| CHEMBL402473 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL320820 | — | Ki | = | 2089.3 | nM | 5.68 |
| CHEMBL612034 | (R)-ACECLIDINE | Ki | = | 2238.72 | nM | 5.65 |
| CHEMBL7303 | ARECOLINE | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL294273 | — | Ki | = | 2754.23 | nM | 5.56 |
| CHEMBL258906 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL259131 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL258905 | — | Ki | = | 5248.07 | nM | 5.28 |
| CHEMBL541424 | — | Ki | = | 9332.54 | nM | 5.03 |
| CHEMBL550 | PILOCARPINE | Ki | = | 12022.64 | nM | 4.92 |
| CHEMBL541424 | — | Ki | = | 15488.17 | nM | 4.81 |
| CHEMBL259662 | — | Ki | = | 37153.52 | nM | 4.43 |
| CHEMBL553241 | — | Ki | = | 77624.71 | nM | 4.11 |
| CHEMBL541424 | — | Ki | = | 81283.05 | nM | 4.09 |