Assay Detail
Binding
CHEMBL923075
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Inhibition of human cathepsin S
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.45 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251117 | — | — | 1 | 9.70 |
| CHEMBL443319 | — | — | 1 | 9.70 |
| CHEMBL251719 | — | — | 1 | 9.70 |
| CHEMBL250720 | — | — | 1 | 9.52 |
| CHEMBL398553 | — | — | 1 | 9.52 |
| CHEMBL400750 | — | — | 1 | 9.52 |
| CHEMBL399063 | — | — | 1 | 9.40 |
| CHEMBL251114 | — | — | 1 | 9.40 |
| CHEMBL400728 | — | — | 1 | 9.30 |
| CHEMBL251327 | — | — | 1 | 9.30 |
| CHEMBL249712 | — | — | 1 | 9.22 |
| CHEMBL427883 | — | — | 1 | 9.15 |
| CHEMBL222649 | — | — | 1 | 8.92 |
| CHEMBL250919 | — | — | 1 | 8.89 |
| CHEMBL251101 | — | — | 1 | 8.74 |
| CHEMBL249915 | — | — | 1 | 8.74 |
| CHEMBL249507 | — | — | 1 | 8.60 |
| CHEMBL400972 | — | — | 1 | 8.30 |
| CHEMBL250121 | — | — | 1 | 8.19 |
| CHEMBL248889 | — | — | 1 | 8.00 |
| CHEMBL400387 | — | — | 1 | 7.96 |
| CHEMBL249698 | — | — | 1 | 7.10 |
| CHEMBL437501 | — | — | 1 | 6.75 |
| CHEMBL249495 | — | — | 1 | 6.58 |
| CHEMBL437579 | — | — | 1 | 6.20 |
| CHEMBL250119 | — | — | 1 | 6.14 |
| CHEMBL436636 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251117 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL443319 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL251719 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL250720 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL398553 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL400750 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL399063 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL251114 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL400728 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL251327 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL249712 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL427883 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL222649 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL250919 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL251101 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL249915 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL249507 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL400972 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL250121 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL248889 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL400387 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL249698 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL437501 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL249495 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL437579 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL250119 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL436636 | — | IC50 | = | 2173.0 | nM | 5.66 |