Assay Detail
Binding
CHEMBL923076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin K
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.94 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437501 | — | — | 1 | 9.70 |
| CHEMBL249495 | — | — | 1 | 9.52 |
| CHEMBL249698 | — | — | 1 | 8.30 |
| CHEMBL248889 | — | — | 1 | 8.28 |
| CHEMBL222649 | — | — | 1 | 8.21 |
| CHEMBL400387 | — | — | 1 | 7.51 |
| CHEMBL249507 | — | — | 1 | 6.85 |
| CHEMBL251719 | — | — | 1 | 6.57 |
| CHEMBL250720 | — | — | 1 | 6.54 |
| CHEMBL251114 | — | — | 1 | 6.52 |
| CHEMBL443319 | — | — | 1 | 6.50 |
| CHEMBL250121 | — | — | 1 | 6.50 |
| CHEMBL400972 | — | — | 1 | 6.42 |
| CHEMBL249915 | — | — | 1 | 6.39 |
| CHEMBL249712 | — | — | 1 | 6.26 |
| CHEMBL436636 | — | — | 1 | 6.19 |
| CHEMBL251117 | — | — | 1 | 6.16 |
| CHEMBL250919 | — | — | 1 | 6.08 |
| CHEMBL250119 | — | — | 1 | 5.95 |
| CHEMBL251327 | — | — | 1 | 5.70 |
| CHEMBL399063 | — | — | 1 | 5.51 |
| CHEMBL400728 | — | — | 1 | - |
| CHEMBL398553 | — | — | 1 | - |
| CHEMBL400750 | — | — | 1 | - |
| CHEMBL427883 | — | — | 1 | - |
| CHEMBL251101 | — | — | 1 | - |
| CHEMBL437579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437501 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL249495 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL249698 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL248889 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL222649 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL400387 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL249507 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL251719 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL250720 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL251114 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL443319 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL250121 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL400972 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL249915 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL249712 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL436636 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL251117 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL250919 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL250119 | — | IC50 | = | 1117.0 | nM | 5.95 |
| CHEMBL251327 | — | IC50 | = | 2003.0 | nM | 5.70 |
| CHEMBL399063 | — | IC50 | = | 3058.0 | nM | 5.51 |
| CHEMBL400728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL398553 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL400750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL251101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL437579 | — | IC50 | > | 10000.0 | nM | - |