Assay Detail
Binding
CHEMBL923078
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Inhibition of human cathepsin L
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.91 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222649 | — | — | 1 | 8.24 |
| CHEMBL250720 | — | — | 1 | 7.82 |
| CHEMBL251114 | — | — | 1 | 7.66 |
| CHEMBL251719 | — | — | 1 | 7.64 |
| CHEMBL443319 | — | — | 1 | 7.62 |
| CHEMBL251117 | — | — | 1 | 7.39 |
| CHEMBL249712 | — | — | 1 | 7.17 |
| CHEMBL400728 | — | — | 1 | 7.07 |
| CHEMBL398553 | — | — | 1 | 6.98 |
| CHEMBL250919 | — | — | 1 | 6.94 |
| CHEMBL400750 | — | — | 1 | 6.92 |
| CHEMBL399063 | — | — | 1 | 6.88 |
| CHEMBL400972 | — | — | 1 | 6.74 |
| CHEMBL251327 | — | — | 1 | 6.73 |
| CHEMBL427883 | — | — | 1 | 6.60 |
| CHEMBL437501 | — | — | 1 | 6.58 |
| CHEMBL400387 | — | — | 1 | 6.37 |
| CHEMBL249698 | — | — | 1 | 6.34 |
| CHEMBL249495 | — | — | 1 | 6.34 |
| CHEMBL250121 | — | — | 1 | 6.04 |
| CHEMBL249507 | — | — | 1 | 5.99 |
| CHEMBL249915 | — | — | 1 | 5.99 |
| CHEMBL251101 | — | — | 1 | - |
| CHEMBL437579 | — | — | 1 | - |
| CHEMBL250119 | — | — | 1 | - |
| CHEMBL248889 | — | — | 1 | - |
| CHEMBL436636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222649 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL250720 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL251114 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL251719 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL443319 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL251117 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL249712 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL400728 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL398553 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL250919 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL400750 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL399063 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL400972 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL251327 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL427883 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL437501 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL400387 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL249698 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL249495 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL250121 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL249507 | — | IC50 | = | 1035.0 | nM | 5.99 |
| CHEMBL249915 | — | IC50 | = | 1013.0 | nM | 5.99 |
| CHEMBL251101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL437579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL250119 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248889 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436636 | — | IC50 | > | 10000.0 | nM | - |