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Assay Detail

CHEMBL923097

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Functional
Antiproliferative activity against mouse tsFT210 cells after 48 hrs by WST-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type tsFT210
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM.
Bioorg Med Chem (2008) 16 : 4626 -4651
PubMed 18321710 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.30 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL259047 1 5.00
CHEMBL260334 1 4.72
CHEMBL409704 1 4.34
CHEMBL261566 1 4.30
CHEMBL258911 1 4.26
CHEMBL409093 1 4.22
CHEMBL411533 1 4.22
CHEMBL409297 1 4.21
CHEMBL289159 TRYPROSTATIN A 1 4.17
CHEMBL411952 1 4.12
CHEMBL260156 1 4.02
CHEMBL430234 1 4.00
CHEMBL261620 1 -
CHEMBL261565 1 -
CHEMBL438414 1 -
CHEMBL258922 1 -
CHEMBL408453 1 -
CHEMBL412283 1 -
CHEMBL258779 1 -
CHEMBL260897 1 -
CHEMBL259846 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL259047 IC50 = 10000.0 nM 5.00
CHEMBL260334 IC50 = 19000.0 nM 4.72
CHEMBL409704 IC50 = 46000.0 nM 4.34
CHEMBL261566 IC50 = 50000.0 nM 4.30
CHEMBL258911 IC50 = 55000.0 nM 4.26
CHEMBL409093 IC50 = 60000.0 nM 4.22
CHEMBL411533 IC50 = 60000.0 nM 4.22
CHEMBL409297 IC50 = 62000.0 nM 4.21
CHEMBL289159 TRYPROSTATIN A IC50 = 68000.0 nM 4.17
CHEMBL411952 IC50 = 75000.0 nM 4.12
CHEMBL260156 IC50 = 96000.0 nM 4.02
CHEMBL430234 IC50 = 100000.0 nM 4.00
CHEMBL261620 IC50 > 100000.0 nM -
CHEMBL261565 IC50 > 100000.0 nM -
CHEMBL438414 IC50 > 100000.0 nM -
CHEMBL258922 IC50 > 100000.0 nM -
CHEMBL408453 IC50 > 100000.0 nM -
CHEMBL412283 IC50 > 100000.0 nM -
CHEMBL258779 IC50 > 100000.0 nM -
CHEMBL260897 IC50 > 100000.0 nM -
CHEMBL259846 IC50 > 100000.0 nM -