Assay Detail
Functional
CHEMBL923239
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Cytotoxicity against human HT1080 cells after 3 days by SRB assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.16 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259989 | — | — | 1 | 8.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL260223 | — | — | 1 | 7.52 |
| CHEMBL261330 | — | — | 1 | 7.48 |
| CHEMBL261342 | — | — | 1 | 7.26 |
| CHEMBL406853 | — | — | 1 | 7.17 |
| CHEMBL259778 | — | — | 1 | 7.14 |
| CHEMBL258925 | — | — | 1 | 7.12 |
| CHEMBL261341 | — | — | 1 | 7.11 |
| CHEMBL261294 | — | — | 1 | 7.07 |
| CHEMBL260541 | — | — | 1 | 7.00 |
| CHEMBL260224 | — | — | 1 | 6.94 |
| CHEMBL261876 | — | — | 1 | 6.69 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.60 |
| CHEMBL259225 | — | — | 1 | 6.48 |
| CHEMBL259990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259989 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL260223 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL261330 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL261342 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL406853 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL259778 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL258925 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL261341 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL261294 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL260541 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL260224 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL261876 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL259225 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL259990 | — | IC50 | > | 5000.0 | nM | - |