Assay Detail
Binding
CHEMBL923241
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Inhibition of human recombinant topoisomerase 2 by decatenation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.34 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261294 | — | — | 1 | 4.71 |
| CHEMBL259225 | — | — | 1 | 4.54 |
| CHEMBL261341 | — | — | 1 | 4.53 |
| CHEMBL260224 | — | — | 1 | 4.48 |
| CHEMBL259778 | — | — | 1 | 4.41 |
| CHEMBL260541 | — | — | 1 | 4.37 |
| CHEMBL261330 | — | — | 1 | 4.35 |
| CHEMBL258925 | — | — | 1 | 4.31 |
| CHEMBL259990 | — | — | 1 | 4.28 |
| CHEMBL261342 | — | — | 1 | 4.26 |
| CHEMBL406853 | — | — | 1 | 4.25 |
| CHEMBL259989 | — | — | 1 | 4.25 |
| CHEMBL261876 | — | — | 1 | 4.21 |
| CHEMBL260223 | — | — | 1 | 4.19 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261294 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL259225 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL261341 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL260224 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL259778 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL260541 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL261330 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL258925 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL259990 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL261342 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL406853 | — | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL259989 | — | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL261876 | — | IC50 | = | 61500.0 | nM | 4.21 |
| CHEMBL260223 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 92900.0 | nM | 4.03 |