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Assay Detail

CHEMBL923558

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of radioligand from rat adenosine A1 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A1 (CHEMBL318)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Melman A, Gao ZG, Kumar D, Wan TC, Gizewski E, Auchampach JA, Jacobson KA.
Bioorg Med Chem Lett (2008) 18 : 2813 -2819
PubMed 18424135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.63 7.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119709 IB-MECA 1 7.27
CHEMBL27376 1 7.08
CHEMBL283057 1 6.09
CHEMBL431733 NAMODENOSON 3.0 1 6.09
CHEMBL2368367 1 -
CHEMBL2368366 1 -
CHEMBL2112157 1 -
CHEMBL2112162 1 -
CHEMBL2368455 1 -
CHEMBL175543 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119709 IB-MECA Ki = 54.0 nM 7.27
CHEMBL27376 Ki = 83.9 nM 7.08
CHEMBL283057 Ki = 805.0 nM 6.09
CHEMBL431733 NAMODENOSON Ki = 820.0 nM 6.09
CHEMBL2368367 Ki - -
CHEMBL2368366 Ki - -
CHEMBL2112157 Ki - -
CHEMBL2112162 Ki - -
CHEMBL2368455 Ki - -
CHEMBL175543 Ki - -