Assay Detail
Binding
CHEMBL923682
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Inhibition of human factor 10a
21
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.41 | 8.05 |
| Ki | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259603 | — | — | 2 | 8.10 |
| CHEMBL405361 | — | — | 1 | 7.92 |
| CHEMBL260152 | — | — | 1 | 7.75 |
| CHEMBL409115 | — | — | 1 | 7.75 |
| CHEMBL265456 | — | — | 1 | 7.70 |
| CHEMBL409851 | — | — | 1 | 7.68 |
| CHEMBL410528 | — | — | 1 | 7.66 |
| CHEMBL258716 | — | — | 1 | 7.62 |
| CHEMBL261775 | — | — | 1 | 7.62 |
| CHEMBL261774 | — | — | 1 | 7.54 |
| CHEMBL409850 | — | — | 1 | 7.46 |
| CHEMBL261323 | — | — | 1 | 7.39 |
| CHEMBL261324 | — | — | 1 | 7.35 |
| CHEMBL265455 | — | — | 1 | 7.24 |
| CHEMBL261646 | — | — | 1 | 7.21 |
| CHEMBL259663 | — | — | 1 | 7.11 |
| CHEMBL261524 | — | — | 1 | 7.06 |
| CHEMBL260360 | — | — | 1 | 7.03 |
| CHEMBL19902 | DX-9065A | — | 1 | 6.89 |
| CHEMBL428081 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259603 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL259603 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL405361 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL260152 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL409115 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL265456 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL409851 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL410528 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL258716 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL261775 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL261774 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL409850 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL261323 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL261324 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL265455 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL261646 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL259663 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL261524 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL260360 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL19902 | DX-9065A | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL428081 | — | IC50 | = | 840.0 | nM | 6.08 |