Assay Detail
Binding
CHEMBL923796
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Displacement of [3H]DHT from androgen receptor expressed in Sf9 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.28 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399439 | — | — | 1 | 7.37 |
| CHEMBL251552 | — | — | 1 | 7.24 |
| CHEMBL399887 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399439 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL251552 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL399887 | — | IC50 | = | 60.0 | nM | 7.22 |