Assay Detail
Functional
CHEMBL923797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.51 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399887 | — | — | 1 | 7.92 |
| CHEMBL251552 | — | — | 1 | 7.89 |
| CHEMBL399439 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399887 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL251552 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL399439 | — | IC50 | = | 196.0 | nM | 6.71 |