Assay Detail
Binding
CHEMBL923872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.11 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160073 | — | — | 1 | 9.15 |
| CHEMBL416409 | — | — | 1 | 9.15 |
| CHEMBL538405 | — | — | 1 | 9.14 |
| CHEMBL429492 | — | — | 1 | 9.10 |
| CHEMBL286991 | — | — | 1 | 9.05 |
| CHEMBL136154 | — | — | 1 | 9.00 |
| CHEMBL409161 | — | — | 1 | 8.96 |
| CHEMBL35122 | — | — | 1 | 8.96 |
| CHEMBL36141 | — | — | 1 | 8.92 |
| CHEMBL34591 | — | — | 1 | 8.92 |
| CHEMBL290799 | — | — | 1 | 8.92 |
| CHEMBL28660 | — | — | 1 | 8.89 |
| CHEMBL255065 | — | — | 1 | 8.89 |
| CHEMBL137020 | — | — | 1 | 8.79 |
| CHEMBL284096 | — | — | 1 | 8.68 |
| CHEMBL36419 | — | — | 1 | 8.64 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.43 |
| CHEMBL159445 | — | — | 1 | 8.39 |
| CHEMBL429840 | — | — | 1 | 8.32 |
| CHEMBL136249 | — | — | 1 | 8.28 |
| CHEMBL285673 | — | — | 1 | 8.24 |
| CHEMBL164270 | — | — | 1 | 8.19 |
| CHEMBL28897 | — | — | 1 | 8.19 |
| CHEMBL35045 | — | — | 1 | 8.10 |
| CHEMBL163272 | — | — | 1 | 8.10 |
| CHEMBL252759 | — | — | 1 | 8.03 |
| CHEMBL34032 | — | — | 1 | 8.00 |
| CHEMBL289013 | — | — | 1 | 7.88 |
| CHEMBL286949 | — | — | 1 | 7.85 |
| CHEMBL35411 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160073 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL416409 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL538405 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL429492 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL286991 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL136154 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL409161 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL35122 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL36141 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL34591 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL290799 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL28660 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL255065 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL137020 | — | Ki | = | 1.61 | nM | 8.79 |
| CHEMBL284096 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL36419 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL281594 | VANOXERINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL159445 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL429840 | — | Ki | = | 4.77 | nM | 8.32 |
| CHEMBL136249 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL285673 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL164270 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL28897 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL163272 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL35045 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL252759 | — | Ki | = | 9.32 | nM | 8.03 |
| CHEMBL34032 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL289013 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL286949 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL35411 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL164297 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL255054 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL403575 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL27748 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL159982 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL252758 | — | Ki | = | 33.7 | nM | 7.47 |
| CHEMBL400707 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL251242 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL28935 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL28414 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL434093 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL28867 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL163163 | — | Ki | = | 61.8 | nM | 7.21 |
| CHEMBL34372 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL255055 | — | Ki | = | 64.6 | nM | 7.19 |
| CHEMBL29000 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL28726 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL254843 | — | Ki | = | 100.0 | nM | 7.00 |