Assay Detail
Binding
CHEMBL923922
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Inhibition of human EGFR autophosphorylation in A431 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248392 | — | — | 1 | 8.30 |
| CHEMBL248393 | — | — | 1 | 8.24 |
| CHEMBL401251 | — | — | 1 | 7.28 |
| CHEMBL248222 | — | — | 1 | 7.17 |
| CHEMBL248044 | — | — | 1 | 7.05 |
| CHEMBL248391 | — | — | 1 | 6.76 |
| CHEMBL399438 | — | — | 1 | 6.63 |
| CHEMBL245798 | — | — | 1 | 6.44 |
| CHEMBL401054 | — | — | 1 | 6.39 |
| CHEMBL248220 | — | — | 1 | 5.79 |
| CHEMBL245800 | — | — | 1 | 5.68 |
| CHEMBL247024 | — | — | 1 | 5.60 |
| CHEMBL248045 | — | — | 1 | 5.59 |
| CHEMBL245799 | — | — | 1 | 5.28 |
| CHEMBL401644 | — | — | 1 | 5.08 |
| CHEMBL248221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248392 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL248393 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL401251 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL248222 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL248044 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL248391 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL399438 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL245798 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL401054 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL248220 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL245800 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL247024 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL248045 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL245799 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL401644 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL248221 | — | IC50 | - | — | - |