Assay Detail
Binding
CHEMBL923923
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Inhibition of ABL
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.35 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248393 | — | — | 1 | 7.36 |
| CHEMBL248392 | — | — | 1 | 6.70 |
| CHEMBL399438 | — | — | 1 | 6.52 |
| CHEMBL248391 | — | — | 1 | 6.52 |
| CHEMBL401251 | — | — | 1 | 6.41 |
| CHEMBL245800 | — | — | 1 | 6.11 |
| CHEMBL248044 | — | — | 1 | 6.02 |
| CHEMBL248222 | — | — | 1 | 5.75 |
| CHEMBL248221 | — | — | 1 | 5.75 |
| CHEMBL247024 | — | — | 1 | - |
| CHEMBL245799 | — | — | 1 | - |
| CHEMBL245798 | — | — | 1 | - |
| CHEMBL401054 | — | — | 1 | - |
| CHEMBL248220 | — | — | 1 | - |
| CHEMBL401644 | — | — | 1 | - |
| CHEMBL248045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248393 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL248392 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL399438 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL248391 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL401251 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL245800 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL248044 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL248222 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL248221 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL247024 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL245799 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL245798 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL401054 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL248220 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL401644 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL248045 | — | Ki | > | 10000.0 | nM | - |