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Assay Detail

CHEMBL923924

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Binding
Inhibition of SYK
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Tyrosine-protein kinase SYK (CHEMBL2599)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.
Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang SH, Bakhirev A, Yang G, Yuen P, Gorcsan F, Sakurai N, Barbosa M, Cheng JF.
Bioorg Med Chem Lett (2007) 17 : 5978 -5982
PubMed 17827009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.75 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL248393 1 7.39
CHEMBL248391 1 6.85
CHEMBL401251 1 6.80
CHEMBL248044 1 6.60
CHEMBL399438 1 6.52
CHEMBL245800 1 6.35
CHEMBL247024 1 -
CHEMBL245799 1 -
CHEMBL245798 1 -
CHEMBL248392 1 -
CHEMBL248222 1 -
CHEMBL248221 1 -
CHEMBL401054 1 -
CHEMBL248220 1 -
CHEMBL401644 1 -
CHEMBL248045 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL248393 Ki = 41.0 nM 7.39
CHEMBL248391 Ki = 140.0 nM 6.85
CHEMBL401251 Ki = 160.0 nM 6.80
CHEMBL248044 Ki = 250.0 nM 6.60
CHEMBL399438 Ki = 300.0 nM 6.52
CHEMBL245800 Ki = 450.0 nM 6.35
CHEMBL247024 Ki > 10000.0 nM -
CHEMBL245799 Ki > 10000.0 nM -
CHEMBL245798 Ki > 10000.0 nM -
CHEMBL248392 Ki > 10000.0 nM -
CHEMBL248222 Ki > 10000.0 nM -
CHEMBL248221 Ki > 10000.0 nM -
CHEMBL401054 Ki > 10000.0 nM -
CHEMBL248220 Ki > 10000.0 nM -
CHEMBL401644 Ki > 10000.0 nM -
CHEMBL248045 Ki > 10000.0 nM -