Assay Detail
Binding
CHEMBL923928
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Inhibition of Abl
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.51 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250213 | — | — | 1 | 10.21 |
| CHEMBL250019 | — | — | 1 | 9.52 |
| CHEMBL250021 | — | — | 1 | 9.40 |
| CHEMBL399246 | — | — | 1 | 9.30 |
| CHEMBL398279 | — | — | 1 | 9.00 |
| CHEMBL400402 | — | — | 1 | 8.89 |
| CHEMBL250821 | — | — | 1 | 8.89 |
| CHEMBL250214 | — | — | 1 | 8.77 |
| CHEMBL399268 | — | — | 1 | 8.77 |
| CHEMBL400403 | — | — | 1 | 8.59 |
| CHEMBL250218 | — | — | 1 | 8.54 |
| CHEMBL249821 | — | — | 1 | 8.52 |
| CHEMBL440963 | — | — | 1 | 8.47 |
| CHEMBL250625 | — | — | 1 | 8.46 |
| CHEMBL398845 | — | — | 1 | 8.46 |
| CHEMBL249819 | — | — | 1 | 8.38 |
| CHEMBL250623 | — | — | 1 | 8.36 |
| CHEMBL231220 | — | — | 1 | 8.30 |
| CHEMBL250423 | — | — | 1 | 8.29 |
| CHEMBL249820 | — | — | 1 | 8.11 |
| CHEMBL436137 | — | — | 1 | 7.96 |
| CHEMBL231524 | — | — | 1 | 7.80 |
| CHEMBL230686 | — | — | 1 | 7.70 |
| CHEMBL251015 | — | — | 1 | 7.62 |
| CHEMBL400303 | — | — | 1 | 7.57 |
| CHEMBL268825 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250213 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL250019 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL250021 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL399246 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL398279 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL400402 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL250821 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL250214 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL399268 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL400403 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL250218 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL249821 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL440963 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL250625 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL398845 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL249819 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL250623 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL231220 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL250423 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL249820 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL436137 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL231524 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL230686 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL251015 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL400303 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL268825 | — | Ki | = | 42.0 | nM | 7.38 |