Assay Detail
Functional
CHEMBL924013
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Vasodilatory effect in pig pulmonary artery assessed as inhibition of PGF2-alpha-induced contraction
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Pulmonary artery |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
NO donors. Part 16: investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pD2 | 15 | - | - |
| EC50 | 15 | 5.61 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609980 | AMINOETHYL NITRATE | 2.0 | 2 | 7.50 |
| CHEMBL730 | NITROGLYCERIN | 4.0 | 2 | 7.45 |
| CHEMBL251410 | — | — | 2 | 6.42 |
| CHEMBL25961 | — | — | 2 | 6.38 |
| CHEMBL6622 | ISOSORBIDE DINITRATE | 4.0 | 2 | 6.37 |
| CHEMBL399905 | — | — | 2 | 5.99 |
| CHEMBL248981 | — | — | 2 | 5.81 |
| CHEMBL401152 | — | — | 2 | 5.02 |
| CHEMBL361225 | — | — | 2 | 4.83 |
| CHEMBL249398 | — | — | 2 | 4.48 |
| CHEMBL399550 | — | — | 2 | 4.47 |
| CHEMBL249808 | PENTAERYTHRITYL MONONITRATE | — | 2 | 4.14 |
| CHEMBL401409 | — | — | 2 | 4.06 |
| CHEMBL401410 | — | — | 2 | - |
| CHEMBL249809 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609980 | AMINOETHYL NITRATE | EC50 | = | 31.5 | nM | 7.50 |
| CHEMBL730 | NITROGLYCERIN | EC50 | = | 35.6 | nM | 7.45 |
| CHEMBL251410 | — | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL25961 | — | EC50 | = | 412.0 | nM | 6.38 |
| CHEMBL6622 | ISOSORBIDE DINITRATE | EC50 | = | 424.0 | nM | 6.37 |
| CHEMBL399905 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL248981 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL401152 | — | EC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL361225 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL249398 | — | EC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL399550 | — | EC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL249808 | PENTAERYTHRITYL MONONITRATE | EC50 | = | 72500.0 | nM | 4.14 |
| CHEMBL401409 | — | EC50 | = | 87700.0 | nM | 4.06 |
| CHEMBL730 | NITROGLYCERIN | pD2 | = | 7.44 | — | - |
| CHEMBL6622 | ISOSORBIDE DINITRATE | pD2 | = | 6.37 | — | - |
| CHEMBL401410 | — | pD2 | = | 3.36 | — | - |
| CHEMBL401410 | — | EC50 | = | 435000.0 | nM | - |
| CHEMBL249809 | — | pD2 | = | 3.85 | — | - |
| CHEMBL249809 | — | EC50 | = | 141000.0 | nM | - |
| CHEMBL401409 | — | pD2 | = | 4.01 | — | - |
| CHEMBL249808 | PENTAERYTHRITYL MONONITRATE | pD2 | = | 4.14 | — | - |
| CHEMBL399550 | — | pD2 | = | 4.48 | — | - |
| CHEMBL361225 | — | pD2 | = | 4.83 | — | - |
| CHEMBL609980 | AMINOETHYL NITRATE | pD2 | = | 7.5 | — | - |
| CHEMBL401152 | — | pD2 | = | 5.02 | — | - |
| CHEMBL251410 | — | pD2 | = | 6.42 | — | - |
| CHEMBL25961 | — | pD2 | = | 6.34 | — | - |
| CHEMBL399905 | — | pD2 | = | 5.99 | — | - |
| CHEMBL249398 | — | pD2 | = | 4.48 | — | - |
| CHEMBL248981 | — | pD2 | = | 5.81 | — | - |