Assay Detail
Functional
CHEMBL924027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.82 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 10.27 |
| CHEMBL250220 | — | — | 1 | 9.47 |
| CHEMBL400582 | — | — | 1 | 9.23 |
| CHEMBL439234 | — | — | 1 | 9.20 |
| CHEMBL250425 | — | — | 1 | 9.01 |
| CHEMBL249426 | — | — | 1 | 9.00 |
| CHEMBL401267 | — | — | 1 | 8.34 |
| CHEMBL429114 | — | — | 1 | 7.75 |
| CHEMBL250221 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL250220 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL400582 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL439234 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL250425 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL249426 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL401267 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL429114 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL250221 | — | IC50 | = | 82.0 | nM | 7.09 |