Assay Detail
Functional
CHEMBL924409
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Growth inhibition of human H460 cells by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.95 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250005 | — | — | 1 | 6.52 |
| CHEMBL248998 | — | — | 1 | 6.35 |
| CHEMBL251012 | — | — | 1 | 6.35 |
| CHEMBL251009 | — | — | 1 | 6.34 |
| CHEMBL248787 | — | — | 1 | 6.32 |
| CHEMBL400760 | — | — | 1 | 6.31 |
| CHEMBL248590 | — | — | 1 | 6.30 |
| CHEMBL251011 | — | — | 1 | 6.28 |
| CHEMBL248797 | — | — | 1 | 6.23 |
| CHEMBL248796 | — | — | 1 | 6.23 |
| CHEMBL400482 | — | — | 1 | 6.17 |
| CHEMBL249198 | — | — | 1 | 6.00 |
| CHEMBL251010 | — | — | 1 | 5.92 |
| CHEMBL442426 | — | — | 1 | 5.75 |
| CHEMBL402719 | — | — | 1 | 5.75 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.47 |
| CHEMBL402718 | — | — | 1 | 5.26 |
| CHEMBL251206 | — | — | 1 | 5.24 |
| CHEMBL248798 | — | — | 1 | 5.13 |
| CHEMBL251406 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250005 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL248998 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL251012 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL251009 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL248787 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL400760 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL248590 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL251011 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL248797 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL248796 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL400482 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL249198 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL251010 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL442426 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL402719 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL402718 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL251206 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL248798 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL251406 | — | IC50 | = | 10400.0 | nM | 4.98 |