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Compound Detail

CHEMBL248798

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COc1cccc(COC(CCCCCC(=O)NO)C(=O)N(Cc2cccc(OC)c2)c2ccccc2)c1

Basic Information

ChEMBL ID CHEMBL248798
Phase Preclinical
Structure Type MOL
InChI Key GQYGFAUYQDPLCF-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

520.6
MW (Da)
5.28
ALogP
6
HBA
2
HBD
97.3
PSA (Ų)
0.16
QED
2
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H36N2O6
MW 520.63
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -0.56

Activity Summary

IC50 4 meas. best 6.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Histone deacetylase 2
CHEMBL1937
IC50 6.3 6.3 500.0 1
NB-4
CHEMBL614188
IC50 5.4 5.4 4000.0 1
NCI-H460
CHEMBL396
IC50 5.13 5.13 7400.0 1
HCT-116
CHEMBL394
IC50 5.12 5.12 7500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17892933 10.1016/j.bmcl.2007.09.014 Histone deacetylase 2 1
17892933 10.1016/j.bmcl.2007.09.014 NB-4 1
17892933 10.1016/j.bmcl.2007.09.014 NCI-H460 1
17892933 10.1016/j.bmcl.2007.09.014 HCT-116 1

Data from ChEMBL 36 via Core Engine