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Target Snapshot

CHEMBL614188 Target Snapshot

NB-4 · CELL-LINE · Homo sapiens

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666Compounds
352Assays
8Approved Drugs
523.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NB-4 as ChEMBL target CHEMBL614188. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NB-4
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614188
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NB-4 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNB-4
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNB-4
UniProt AccessionN/A

NB-4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NB-4.

Review nameNB-4
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
2
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50515.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4790597 9.76 IC50 0.173 Preclinical
CHEMBL5428441 9.4 IC50 0.4 Preclinical
CHEMBL5421145 9.22 IC50 0.6 Preclinical
CHEMBL5416318 9.15 IC50 0.7 Preclinical
CHEMBL566757 8.7 IC50 2.0 Clinical
CHEMBL4170596 8.7 IC50 2.0 Preclinical
CHEMBL4765060 8.44 IC50 3.601 Preclinical
CHEMBL555196 8.4 IC50 4.0 Preclinical
CHEMBL5592221 8.31 IC50 4.94 Preclinical
CHEMBL1090479 7.96 EC50 11.0 Preclinical
Distribution

pChEMBL Value Distribution

81
5.0
95
5.5
66
6.0
29
6.5
13
7.0
11
7.5
3
8.0
2
8.5
3
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

QUIZARTINIB
CHEMBL576982
Approved 2023
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
ARSENIC TRIOXIDE
CHEMBL5483015
Approved 2000
Properties Compare Identifier
IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

352
Total Assays
367
Tested Compounds
2
Assay Types
Functional — 350 assays, 367 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 344 367 5.7
organism-based format 6 0 —
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine