Skip to main content
Evidence Snapshot

NB-4

CHEMBL614188 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:26:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614188
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NB-4 as ChEMBL target CHEMBL614188. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NB-4
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614188
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why NB-4 matters

As of 2026-09-13

NB-4 is reviewed as NB-4; the current evidence base includes 8 approved drugs, 666 compounds, and 352 assays, with lead potency reaching pChEMBL 9.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 8 approved drugs, 666 compounds, and 352 assays for this target. The dominant activity type is IC50. CHEMBL4790597 is the current potency anchor at pChEMBL 9.8.

Use CHEMBL4790597 as the tractability anchor when discussing potency (pChEMBL 9.8).

Activity source · ChEMBL 36 via Core Engine
8 approved pChEMBL 9.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why NB-4 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

666
Total Compounds
352
Total Assays
8
Approved Drugs
IC50: 515.0, EC50: 8.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4790597
 9.8 IC50 —
No preferred name
CHEMBL5428441
 9.4 IC50 —
No preferred name
CHEMBL5421145
 9.2 IC50 —
No preferred name
CHEMBL5416318
 9.2 IC50 —
No preferred name
CHEMBL566757
 8.7 IC50 Clinical

Approved Drugs

Structure Compound First Approval
QUIZARTINIB
CHEMBL576982
 2023
VORINOSTAT
CHEMBL98
 2006
ARSENIC TRIOXIDE
CHEMBL5483015
 2000
IRINOTECAN
CHEMBL481
 1996
PACLITAXEL
CHEMBL428647
 1992
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
 1974
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:26:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614188