Assay Detail
Binding
CHEMBL924478
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Displacement of [3H]nisoxetine from NET in rat brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.69 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246388 | — | — | 1 | 6.29 |
| CHEMBL246118 | — | — | 1 | 6.04 |
| CHEMBL245915 | — | — | 1 | 5.98 |
| CHEMBL394320 | — | — | 1 | 5.96 |
| CHEMBL245913 | — | — | 1 | 5.56 |
| CHEMBL246119 | — | — | 1 | 5.26 |
| CHEMBL246120 | — | — | 1 | 4.75 |
| CHEMBL22183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246388 | — | Ki | = | 518.0 | nM | 6.29 |
| CHEMBL246118 | — | Ki | = | 919.0 | nM | 6.04 |
| CHEMBL245915 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL394320 | — | Ki | = | 1083.0 | nM | 5.96 |
| CHEMBL245913 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL246119 | — | Ki | = | 5550.0 | nM | 5.26 |
| CHEMBL246120 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL22183 | — | Ki | - | — | - |